I am a fan of Transformers Prime the show. I do not collect the figures.
I have Slipstream, and my first thought was "looks too much like starscream" and now all I can imagine is Slipstream speaking with a deeper Starscream voice akin to Dr. Ms. The Monarch (aka Dr. Girlfriend) from Venture Brothers.
Looks at home with Botcon Megaplex (with reg. head or Renderform head) as well as GDO Cliffjumper. But overall it doesn't sell me (personally) on Slipstream, just a different headed Starscream in a purple and teal deco. For Prime collectors it would be a nice addition. But doesn't really fit in a classic setup although some (my brother) think she does.