While there was a time I anxiously awaited Duke Nukem forever, that ended at least 8 years ago with the project becoming one of the longest running jokes in video game history. If the game actually does come out, I'll probably still check it out but I just don't see it living up to its development time, its hype, or any current standard for greatness.
Fingers crossed, mind you. But I foresee a fairly generic FPS that will be too afraid to go for the full 'Duke-ishness' that we want and cater to a more conservative demographic in hoping of reaching the masses instead of the dedicated fanbase. In all fairness, I still wouldn't mind seeing a current gen rendition of the OctaBrain or Pig cops.