You mean a live-action Transformers TV show? It certainly would be interesting... *but* you need to remember that even nowadays the digital SFX on TV series are still limited in scope/duration. I think it would likely still be far too expensive to have most of a TV series' characters be CGI, so you'd have to limit the number/exposure of the TFs... and you know how cranky the fans get if the writers dare show a human for more than five seconds, so that won't work.

Personally, I'd love to see a fully-animated adult TF show. There's still so very little adult animation that isn't either anime or "edgy humor"... I wish US TV would finally get over the notion that animation must either be Japanese, kiddie, or comedy.
(In fact, the only series I can even recall off-hand is Aeon Flux... and that was initially relegated to MTV's animation anthology show Liquid Television before it finally got its own brief series.)