While the paint defects, overspray and scratches have been common, they vary wildly from one sample to the next. The defect that has come up often is that one of the slots for Saber's nosecone has not been cut out. It is the most recurring defect attributed to sculpting so far and it prevents the nosecone from attaching properly to form the alt mode. There has also been a report from fellow Seibertronian Cloudbaloon that the handle to their V-Lock Canon is missing. And lastly, the face flap for Victory Leo is very tight, which can lead to breakage, as you can see in the image below from Thebricklord.
For MISB collectors, the box isn't actually sealed, so checking for these issues would not result in unsealing the box.